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Novabel1 : Letter to Customers : Suspension of Shipments

Farnham UK, 30 June 2010: Biocompatibles International plc (LSE:BII), the medical technology company, is announcing the decision of its licencee and marketing partner, Merz Pharmaceuticals GmbH, to write a letter to its customers and temporarily suspend shipments of Novabel.

The letter states:

“It has been just over 5 months since Merz Aesthetics launched the unique, aesthetics injectable filler Novabel in 7 EU Countries. Novabel has been successfully used in multiple areas of the face generating high levels of physician and patient satisfaction.

As part of our commitment to open communication we wish to advise you of recently reported adverse reactions in a few patients treated with Novabel, most commonly in the infra-orbital area. Given the unique nature of Novabel, an effective treatment has not yet been identified to quickly resolve these events. As patient and physician satisfaction is a critical component of continued Novabel success, Merz will temporarily suspend all sales, product shipping and promotional efforts of Novabel pending the availability of effective treatment protocols appropriate for highly sensitive areas.”

The two companies are therefore now developing these treatment protocols with materials and techniques that are in routine medical practice. The procedures will be similar to those currently available for conventional fillers and, subject to validation of these techniques, the two companies intend that shipments to physicians would resume in the near future.

Crispin Simon, Chief Executive of Biocompatibles, commented:

“I am confident that our CellMed team will have a safe and effective technique for sensitive areas ready for evaluation in the next few weeks.”

Steve Basta, Chief Executive of Merz Aesthetics, commented :

“We remain very positive and excited about the many, unique benefits Novabel offers doctors and patients.”

Biocompatibles confirms that there is no change to the 2010 financial guidance that was last updated on 16th June and will provide an update on progress of the technique project with the publication of the Interim Results on August 26th.

-Ends-

1 Novabel is a registered trademark of Merz Pharmaceuticals GmbH, Biocompatibles’ licencee and marketing partner.

Contact:

Biocompatibles
Crispin Simon, Chief Executive
Ian Ardill, Finance Director
+44 (0) 1252 732706
   
Anna Keeble +44 (0) 7879 818876

 

Regulatory notices and product safety data

Worldwide (excluding USA)

Bead Block™ is CE marked and indicated for the treatment of a variety of hypervascular tumours (including Uterine Fibroids) and arteriovenous malformations (AVMs). For full prescribing information please refer to Bead Block instructions for use.

DC Bead® is CE marked and is indicated for the treatment of malignant hypervascular tumours and loading with doxorubicin drug. DC Bead® is also indicated for loading with irinotecan for the treatment of metastatic colorectal cancer (mCRC). Both indications may not be available in your territory. For full prescribing information please refer to DC Bead instructions for use.

DC BeadM1™ is indicated for loading with irinotecan for the treatment of metastatic colorectal cancer (mCRC). For full prescribing information please refer to DC Bead M1 instructions for use.

USA

In the USA, Bead Block™ is indicated for the treatment of hypervascular tumors and arteriovenous malformations (AVMs). For full prescribing information please refer to Bead Block USA Instructions for use.

LC Bead™ is cleared by the FDA for the embolization of hypervascular tumors and arteriovenous malformations (AVMs). For full prescribing information please refer to LC Bead instructions for use.

LC Bead M1™ is cleared by the FDA for the embolization of hypervascular tumors and arteriovenous malformations (AVMs). For full prescribing information please refer to LC Bead M1 instructions for use.

DC Bead is not currently available for sale or distribution in the USA. Both indications may not be available in your territory. 

DC Bead M1 is not currently available for sale or distributions in the USA. 

Canada

DC Bead® with doxorubicin is indicated for trans-arterial chemoembolization (TACE) of unresectable hepatocellular carcinoma (HCC). DC Bead are also intended to be loaded with irinotecan for the purpose of embolization of vessels supplying malignant colorectal cancer metastasised to the liver (mCRC), and delivery of a local, controlled, sustained dose of irinotecan to the mCRC. For full prescribing information please refer to DC Bead Canada Instructions for Use 

DC BeadM1 is primarily intended as an embolic agent to treat vessels supplying malignant colorectal cancer metastasised to the liver (mCRC). DC BeadM1 is also compatible with irinotecan, which can be loaded prior to embolisation and then, as a secondary action, elute a local, controlled and sustained dose to the mCRC after embolisation. For full prescribing information please refer to DC BeadM1 Canada Instructions for Use  

Tawain

DC Bead is approved by the Department of Health and is intended to be loaded with Mayne (Hospira) doxorubicin HCI for the purpose of embolisation of vessels supplying malignant hypervascularised tumour(s), and delivery of a local, controlled, sustained dose of doxorubicin.  DC Bead is also indicated for the embolisation of nidus vessels without medication.  Approved size ranges in Taiwan are 300-500µm and 500-700µm.

Hong Kong

PRECISION Bead™ is indicated for the delivery of Doxorubicin, a chemotherapeutic agent for the treatment of malignant hypervascular tumours, where Trans Arterial Embolisation (TAE) is not contraindicated.