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Recommended Acquisition by BTG plc of Biocompatibles International plc

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Summary
The Boards of BTG and Biocompatibles are pleased to announce that they have reached agreement on the terms of a recommended proposal whereby BTG will acquire the entire issued and to be issued share capital of Biocompatibles.

Both Boards believe that the transaction will create a fast-growing, financially stronger, international specialist healthcare business.

The BTG Board views the acquisition of Biocompatibles as an excellent opportunity to combine Biocompatibles' fast growing specialist products with BTG's existing commercial infrastructure. The enhanced resources of the Enlarged Group will allow accelerated investment in Biocompatibles' products and development pipeline. The Biocompatibles Board views the acquisition by BTG as an excellent opportunity to exploit further the potential of the strong platform which has been built to date. Biocompatibles Shareholders will benefit from a successful company with a broad portfolio of products (both directly marketed and partnered) and the significant upside potential in the combined development pipeline.

Defined terms used in this announcement have the meanings set out in Appendix IV to this announcement.

Enquiries:

BTG
Louise Makin, Chief Executive Officer
Rolf Soderstrom, Chief Financial Officer
Andy Burrows, Director of Investor Relations


+44 (0)20 7575 0000
+44 (0)20 7575 0000
+44 (0)20 7575 1741

   

Biocompatibles
Crispin Simon, Chief Executive Officer
Ian Ardill, Chief Financial Officer


+44 (0)1252 732706
+44 (0)1252 732706

   

Rothschild (financial adviser and joint sponsor to BTG)
Dominic Hollamby
Julian Hudson


+44 (0)20 7280 5000
+44 (0)20 7280 5000

   

J.P. Morgan Cazenove (joint sponsor and corporate broker to BTG)
James Mitford
Gina Gibson


+44 (0)20 7742 4000
+44 (0)20 7742 4000

   

Piper Jaffray (financial adviser to Biocompatibles)
Rupert Winckler
James White


+44 (0)20 3142 8700
+44 (0)20 3142 8700

   

Nomura Code (corporate broker to Biocompatibles)
Chris Collins


+44 (0)20 7776 1200

   

Financial Dynamics (financial public relations adviser to BTG)
Ben Atwell
John Dineen


+44 (0)20 7831 3113
+44 (0)20 7831 3113

   

Anna Keeble (financial public relations adviser to Biocompatibles)
Anna Keeble


+44 (0)78 7981 8876

   

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Regulatory notices and product safety data

Worldwide (excluding USA)

Bead Block™ is CE marked and indicated for the treatment of a variety of hypervascular tumours (including Uterine Fibroids) and arteriovenous malformations (AVMs). For full prescribing information please refer to Bead Block instructions for use.

DC Bead® is CE marked and is indicated for the treatment of malignant hypervascular tumours and loading with doxorubicin drug. DC Bead® is also indicated for loading with irinotecan for the treatment of metastatic colorectal cancer (mCRC). Both indications may not be available in your territory. For full prescribing information please refer to DC Bead instructions for use.

DC BeadM1™ is indicated for loading with irinotecan for the treatment of metastatic colorectal cancer (mCRC). For full prescribing information please refer to DC Bead M1 instructions for use.

USA

In the USA, Bead Block™ is indicated for the treatment of hypervascular tumors and arteriovenous malformations (AVMs). For full prescribing information please refer to Bead Block USA Instructions for use.

LC Bead™ is cleared by the FDA for the embolization of hypervascular tumors and arteriovenous malformations (AVMs). For full prescribing information please refer to LC Bead instructions for use.

LC Bead M1™ is cleared by the FDA for the embolization of hypervascular tumors and arteriovenous malformations (AVMs). For full prescribing information please refer to LC Bead M1 instructions for use.

DC Bead is not currently available for sale or distribution in the USA. Both indications may not be available in your territory. 

DC Bead M1 is not currently available for sale or distributions in the USA. 

Canada

DC Bead® with doxorubicin is indicated for trans-arterial chemoembolization (TACE) of unresectable hepatocellular carcinoma (HCC). DC Bead are also intended to be loaded with irinotecan for the purpose of embolization of vessels supplying malignant colorectal cancer metastasised to the liver (mCRC), and delivery of a local, controlled, sustained dose of irinotecan to the mCRC. For full prescribing information please refer to DC Bead Canada Instructions for Use 

DC BeadM1 is primarily intended as an embolic agent to treat vessels supplying malignant colorectal cancer metastasised to the liver (mCRC). DC BeadM1 is also compatible with irinotecan, which can be loaded prior to embolisation and then, as a secondary action, elute a local, controlled and sustained dose to the mCRC after embolisation. For full prescribing information please refer to DC BeadM1 Canada Instructions for Use  

Tawain

DC Bead is approved by the Department of Health and is intended to be loaded with Mayne (Hospira) doxorubicin HCI for the purpose of embolisation of vessels supplying malignant hypervascularised tumour(s), and delivery of a local, controlled, sustained dose of doxorubicin.  DC Bead is also indicated for the embolisation of nidus vessels without medication.  Approved size ranges in Taiwan are 300-500µm and 500-700µm.

Hong Kong

PRECISION Bead™ is indicated for the delivery of Doxorubicin, a chemotherapeutic agent for the treatment of malignant hypervascular tumours, where Trans Arterial Embolisation (TAE) is not contraindicated.