Data presented on DC Bead loaded with epirubicin

Abstract:

Using Epirubicin-loaded DC Bead for Superselective Embolisation of Hepatocellular Carcinoma: Initial Experiences

Abstract No:

401

Author:

J Wiskirchen, et al (Germany)

Presented:

Society of Interventional Radiology (SIR), March 2007

Purpose:

The aim of the study is to describe our first experiences with epirubicin-loaded DC Bead in the treatment of Hepatocellular carcinoma.

Materials & Methods:

In the past 14 months, 20 patients (2 female, 18 male, mean age 66.7 years) were treated by transarterial chemoembolisation with epirubicin-loaded particles. 7 patients had 1 nodule larger than 5 cm in diameter, 5 of those 8 patients had a nodule larger than 10cm in diameter. 11 patients were treated once so far, 8 patients twice, and one patient already 5 times. The standard dose was 2mL DC Bead (size 300 - 500µ) in combination with 50mg epirubicin. However, in 3 cases a double dose was chosen, i.s. 4mL DC Bead enriched with 100mg epirubicin. In all cases, chemoembolisation was performed super-selectively using a 2.7-F microcatheter.

Results:

Thus far, all patients treated with epirubicin-loaded DC Bead are alive, including the first 4 patients who survived at least 12 months (mean 12.5 months) since the first treatment. Overall, the treatment was well tolerated. All patients presented with elevated liver enzymes one day after the embolisation. Additionally, 4 patients suffering from large HCCs complained about abdominal pain three weeks after the embolisation. An MRI showed a necrotic liver tumour and a fistula between the tumour and the duodenum.

Conclusion:

Using epirubicin-loaded particles might be beneficial in the transarterial treatment of Hepatocellular carcinoma. So far, we did not lose any patient in a period of 14 months (August 2005 - September 2006), however long-term follow-up is needed. Overall, the treatment was well tolerated. Patients with large tumours might suffer from pain, nausea and/or fever, especially when higher doses of DC Bead (more than one vial) and epirubicin are used.

 

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