Uterine Fibroid Embolisation (UFE)

James Lyon, MD
Sharp Memorial Hospital, San Diego, USA

Patient History

  • 48-year-old female with 3-year history of menorrhagia with symptomatic fibroids.
  • Hysteroscopic resection of a submucosal fibroid attempted but unsuccessful.

Bead Block Case 9 fig 1
Pre-aortogram

Procedure

  • UFE performed using a 6Fr sheath introduced into the right common femoral artery.
  • Initial aortogram performed assessing traditional supply to the fibroids.
  • A 5Fr Cobra 2 Glidecath was advanced over the aortic bifurcation into the left hypogastric artery.
  • The uterine artery was catheterised to its distal ascending segment using a .014” wire and microcatheter.
  • Angiogram confirmed placement of the microcatheter distal to the cervical-vaginal branch and proximal to the first fibroid branch.
  • Peri-fibroid plexus vessels were incrementally embolised using a total of 2ml of 500-700μm and 1ml of 700-900μm Bead Block microspheres until complete occlusion.
  • The right hypogastric artery was then catheterised and the microcatheter reintroduced into the right uterine artery.
  • The right uterine artery was then embolised using 2ml of 500-700μm Bead Block microspheres until complete occlusion.

Outcome

  • Final aortogram confirmed devascularisation without anomalous arterial blood supply.
Bead Block Case 9 fig 2

Pre-embolisation: left uterine artery

Bead Block Case 9 fig 3

Pre-embolisation: right uterine artery

Bead Block Case 9 fig 4

Post-embolisation: left uterine artery

Bead Block Case 9 fig 5

Post-embolisation: right uterine artery

Bead Block Case 9 fig 6

Post-aortogram

Regulatory notices and product safety data

Worldwide (excluding USA)

Bead Block™ is CE marked and indicated for the treatment of a variety of hypervascular tumours (including Uterine Fibroids) and arteriovenous malformations (AVMs). Bead Blockā„¢ may not be indicated for the treatment of Uterine Fibroids in your country, please check with your local distributor. For full prescribing information please refer to Bead Block instructions for use.

USA

Bead Block is intended to be used for the embolization of hypervascular tumors and arteriovenous malformations (AVMs)

Bead Block Cautions:

  • Do not use if the syringe or packaging appear damaged
  • Sterile and single use product.  Do not reuse
  • Select the size and quantity of Bead Block microspheres appropriate for the pathology to be treated
  • Embolization with Bead Block microspheres should only be performed by physicians who have received appropriate interventional occlusion training in the region intended to be embolized

For instructions for use, please refer to www.biocompatibles.com/beadblock-ifu

Bead Block Potential Complications:

  • Undesirable reflux or passage of Bead Block into normal arteries adjacent to the targeted lesion or through the lesion into other arteries or arterial beds, such as the internal carotid artery, pulmonary, or coronary circulations
  • Pulmonary embolization
  • Ischemia at an undesirable location
  • Capillary bed saturation and tissue damage
  • Ischemic stroke or ischemic infarction
  • Vessel or lesion rupture and haemorrhage
  • Neurological deficits including cranial nerve palsies
  • Vasospasm
  • Death
  • Recanalization
  • Foreign body reactions necessitating medical intervention
  • Infection necessitating medical intervention
  • Clot formation at the tip of the catheter and subsequent dislodgement