Literature

Doxorubicin-eluting bead-enhanced radiofrequency ablation of hepatocellular carcinoma: A pilot clinical study

Journal Journal of Hepatology
Date Published August 2008, published online April 2008
Author(s) Lencioni R, Crocetti L, Petruzzi P, et al
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Chemoembolization (TACE) of Unresectable Intrahepatic Cholangiocarcinoma with Slow-Release Doxorubicin-Eluting Beads: Preliminary Results

Journal Cardiovasc Intervent Radiol (CVIR)
Date July 2008
Author(s) C Aliberti, G Benea, M Tilli, et al
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Transarterial Chemoembolization of Liver Metastases from Well Differentiated Gastroenteropancreatic Endocrine Tumors with Doxorubicin-eluting Beads: Preliminary Results

Journal JVIR (2008) Volume 19, No. 855-861
Date Published June 2008, published online March 2008
Author(s) De Baere T, Deschamps F, Teriitheau C, et al
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Transarterial Chemoembolization of Unresectable Hepatocellular Carcinoma with Drug Eluting Beads: Results of an Open-Label Study of 62 Patients

Journal CVIR
Date Published March-April 2008, published online November 2007
Author(s) Malagari K, Chatzimichael K, Alexopoulou E, et al
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Preservation of the active lactone form of irinotecan using drug eluting beads for the treatment of colorectal cancer metastases

Journal Journal of Controlled Release
Date Published April 2008, published online December 2007
Author(s) Y Tang, P R Czuczman, S T Chung et al
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Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin

Journal Clinical and Experimental Metastasis
Date Published June 2008, published online February 2008
Author(s) Eyol E, Boleij A, Taylor R et al
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Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results

Journal Cardiovasc Intervent Radiology (CVIR)
Date Published May-June 2008, published online February 2008
Author(s) J Kettenbach, A Stadler, I van Katzler, et al (J Lammer)
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Transcatheter chemoembolization in the treatment of HCC in patients not eligible for curative treatments: midterm results of doxorubicin-loaded DC Bead

Journal Abdominal Imaging
Date Published September-October 2008
Author(s) Malagari K, Axexopoulou E, Chatzimichail K, et al
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Intraarterial Hepatic Chemoembolization of Liver Metastases from Colorectal Cancer Adopting Irinotecan-eluting Beads: Results of a Phase II Clinical Study

Journal In Vivo - International Journal of Experimental and Clinical Pathophysiology and Drug Research
Date Published November-December 2007
Author(s) Fiorentini G, Aliberti C, Turrisi G, et al
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A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial Drug-Eluting Bead

Journal Clinical Gastroenterology and Hepatology
Date Published September 2007, published online July 2007
Author(s) Poon R, Tso W, Pang R, et al
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Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics

Journal Journal of Hepatology
Date Published March 2007, published online November 2006
Author(s) Varela M, Real M, Burrel M et al
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Doxorubicin-Eluting Beads - 2: Methods for evaluating drug elution and in-vitro : in-vivo correlation

Journal Journal of Materials Science
Date Published February 2008, published online July 2007
Author(s) Gonzalez V, Tang Y, Phillips G, et al
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Doxorubicin-Eluting Beads - 1: Effects of drug loading on bead characteristics and drug distribution

Journal Journal of Materials Science
Date Published September 2007, published online May 2007
Author(s) Lewis A, Gonzalez V, Leppard S, et al
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Drug-Eluting Beads: A new paradigm for the treatment of primary Liver Cancer

Journal European Journal for Hospital Pharmacy
Date December 2006
Author(s) Gonzalez V, Watkinson A, et al
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Trans-arterial Chemoembolisation (TACE) of Liver Metastases from Colorectal Cancer using Irinotecan-Eluting Beads: Preliminary Results

Journal Anticancer Research (International Journal of Cancer Research and Treatment)
Date Published September-October 2006
Author(s) Aliberti C, Tilli M, Benea G & Fiorentini G
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Irinotecan Drug Eluting Beads for use in Chemoembolisation: In Vitro and In Vivo evaluation of Drug release properties

Journal European Journal of Pharmaceutical Sciences
Date Published January 2007, published online September 2006
Author(s) Taylor R, Lewis A, et al
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Pharmacokinetic and Safety Study of Doxorubicin-Eluting Beads in a Porcine Model of Hepatic Arterial Embolisation

Journal Journal of Vascular and Interventional Radiology
Date Published August 2006
Author(s) Taylor R, Lewis A, et al
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New Intra-arterial Drug Delivery System for the treatment of Liver Cancer

Journal Clinical Cancer Research (American Association for Cancer Research)
Date Published April 2006
Author(s) Hong K, et al
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DC Bead: In Vitro Characterisation of a Drug-Delivery Device for Transarterial Chemoembolisation

Journal Journal of Vascular and Interventional Radiology
Date Published February 2006
Author(s) Lewis A, Gonzalez M, Lloyd A, et al
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Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial

Journal The Lancet
Date May 2002
Author(s) Llovet J, Real M, Montana X et al
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Regulatory notices and product safety data

Worldwide (excluding USA and Canada)

DC Bead® is CE marked and is indicated for the treatment of malignant hypervascular tumours and loading with doxorubicin drug. DC Bead® is also indicated for loading with irinotecan for the treatment of metastatic colorectal cancer (mCRC). For full prescribing information please refer to DC Bead instructions for use.

USA

DC Bead is not currently available for sale or distribution in the USA. DC Bead has not been submitted for approval to the FDA.

Canada

DC Bead® with doxorubicin is indicated for trans-arterial chemoembolization (TACE) of unresectable hepatocellular carcinoma (HCC). DC Bead are also intended to be loaded with irinotecan for the purpose of embolization of vessels supplying malignant colorectal cancer metastasised to the liver (mCRC), and delivery of a local, controlled, sustained dose of irinotecan to the mCRC. For full prescribing information please refer to DC Bead Canada Instructions for Use 

Tawain

DC Bead is approved by the Department of Health and is intended to be loaded with Mayne (Hospira) doxorubicin HCI for the purpose of embolisation of vessels supplying malignant hypervascularised tumour(s), and delivery of a local, controlled, sustained dose of doxorubicin.  DC Bead is also indicated for the embolisation of nidus vessels without medication.  Approved size ranges in Taiwan are 300-500µm and 500-700µm.