Literature

Intra-arterial Infusion of Irinotecan-loaded Drug-eluting Beads (DEBIRI) versus Intravenous Therapy (FOLFIRI) for Hepatic Metastases from Colorectal Cancer: Final Results of a Phase III Study

Journal Anticancer Research
Date April 2012
Author(s) G Fiorentini, C Aliberti, M Tilli et al
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Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using DC Beads. Implications for clinical practice and trial design.

Journal Journal of Hepatology
Date Accepted for publication January 2012
Author(s) M Burrel, M Reig, A Forner et al
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Hepatic Arterial Chemoembolization Adopting DC Bead, Drug-Eluting Bead Loaded with Irinotecan (DEBIRI) Versus Systemic Therapy for Hepatic Metastases from Colorectal Cancer: A Randomized Study of Efficacy and Quality of Life

Journal Annals of Gastroenterology & Hepatology
Date Accepted for publication 2011, to be published March 2012
Author(s) G Fiorentini, C Aliberti, G Benea et al
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Conventional versus Doxorubicin-eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma

Journal JVIR
Date November 2011
Author(s) R Sacco, I Bargellini, M Bertini et al
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Transcatheter Treatment of Hepatocellular Carcinoma with Doxorubicin-loaded DC Bead (DEBDOX): Technical Recommendations

Journal CVIR
Date October 2011
Author(s) R Lencioni, T de Baere, M Burrel et al
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Phase II Trial of Sorafenib Combined With Concurrent Transarterial Chemoembolization With Drug-Eluting Beads for Hepatocellular Carcinoma

Journal Journal of Clinical Oncology
Date October 2011
Author(s) T Pawlik, D Reyes, D Cosgrove et al
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Hepatic Arterial Infusion of Doxorubicin-Loaded Microshere for Treatment of Hepatocellular Cancer: A Multi-Institutional Registry

Journal Journal of the American College of Surgeons
Date October 2011
Author(s) R Martin, L Rustein, DP Enguix et al
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Hepatic Arterial Therapy as a Bridge to Ablation or Transplant in the Treatment of Hepatocellular Carcinoma

Journal The American Surgeon
Date July 2011
Author(s) R Farmer, I Kralj, A Valdata et al
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Drug-eluting bead loaded with doxorubicin versus conventional Lipiodol-based transarterial chemoembolization in the treatment of hepatocellular carcinoma: a case-control study of Asian patients

Journal European Journal of Gastroenterology & Hepatology
Date June 2011
Author(s) M Song, C Park, J Kim et al
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Embolization of hepatocellular carcinoma with drug-eluting beads: Doxorubicin tissue concentration and distribution in patient liver explants

Journal Journal of Hepatology
Date Epub May 2011
Author(s) J Namur, S Citron, M Sellers et al
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Optimal technique and response of doxorubicin beads in hepatocellular cancer: bead size and dose

Journal The Korean Journal of Hepatology
Date March 2011
Author(s) R Martin, J Irurzun, J Munchart et al
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Hepatectomy after hepatic arterial therapy with either yttrium-90 or drug-eluting bead chemotherapy: is it safe?

Journal HPB
Date February 2011
Author(s) RE Brown, MR Bower, TL Metzger et al
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Imaged Guided Transarterial Chemoembolization with Drug-Eluting Beads Loaded with Doxorubicin (DEBDOX) for Hepatic Metastases from Melanoma: Early Outcomes from a Multi-Institutional Registry

Journal The American Surgeon
Date January 2011
Author(s) R Brown, K Gibler, T Metzger et al
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Transcatheter Arterial Chemoembolization for Liver Cancer: Is It Time to Distinguish Conventional from Drug-Eluting Chemoembolization?

Journal CVIR
Date Published February 2011, published online November 2010
Author(s) Liapi E & Geschwind JF
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Toxicity of Irinotecan-Eluting Beads in the Treatment of Hepatic Malignancies: Results of a Multi-Institutional Registry

Journal CVIR
Date Published October 2010, published online July 2010
Author(s) R Martin, J Howard, D Tomalty et al
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Contrast-Enhanced Ultrasonography of Hepatocellular Carcinoma After Chemoembolisation Using Drug-Eluting Beads: A Pilot Study Focused on Sustained Tumor Necrosis

Journal CVIR
Date Published October 2010, published online January 2010
Author(s) H Moschouris, K Malagari, M G Papadaki et al
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Precision Hepatic Arterial Irinotecan Therapy in the Treatment of Unresectable Intrahepatic Cholangiocellular Carcinoma: Optimal Tolerance and Prolonged Overall Survival

Journal Annals of Surgical Oncology
Date Published February 2011, published online September 2010
Author(s) S Schiffman, T Metzger, G Dubel et al
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Hepatic Intra-Arterial Injection of Drug-Eluting Bead, Irinotecan (DEBIRI) in Unresectable Colorectal Liver metastases Refractory to Systemic Chemotherapy: Results of Multi-Institutional Study

Journal Annals of Surgical Oncology
Date Published January 2011, published online August 2010
Author(s) Martin R, Joshi J, Robbins K et al
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To Bead or Not to Bead: is Transarterial Chemoembolization with Doxorubicin-eluting Beads a New Standard of Care in Hepatocellular Carcinoma?

Journal Gastroenterology
Date Published August 2010, published online June 2010
Author(s) J Trojan & S Zeuzem
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Loco-Regional Treatment of Hepatocellular Carcinoma

Journal Hepatology
Date Published August 2010, published online April 2010
Author(s) Lencioni R
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Regulatory notices and product safety data

Worldwide (excluding USA and Canada)

DC Bead® is CE marked and is indicated for the treatment of malignant hypervascular tumours and loading with doxorubicin drug. DC Bead® is also indicated for loading with irinotecan for the treatment of metastatic colorectal cancer (mCRC). For full prescribing information please refer to DC Bead instructions for use.

USA

DC Bead is not currently available for sale or distribution in the USA. DC Bead has not been submitted for approval to the FDA.

Canada

DC Bead® with doxorubicin is indicated for trans-arterial chemoembolization (TACE) of unresectable hepatocellular carcinoma (HCC). DC Bead are also intended to be loaded with irinotecan for the purpose of embolization of vessels supplying malignant colorectal cancer metastasised to the liver (mCRC), and delivery of a local, controlled, sustained dose of irinotecan to the mCRC. For full prescribing information please refer to DC Bead Canada Instructions for Use 

Tawain

DC Bead is approved by the Department of Health and is intended to be loaded with Mayne (Hospira) doxorubicin HCI for the purpose of embolisation of vessels supplying malignant hypervascularised tumour(s), and delivery of a local, controlled, sustained dose of doxorubicin.  DC Bead is also indicated for the embolisation of nidus vessels without medication.  Approved size ranges in Taiwan are 300-500µm and 500-700µm.